• Ivy Exec
  • $76,040.00 -129,110.00/year*
  • Ridgefield , CT
  • Scientific Research
  • Full-Time
  • 58 High Ridge Ave

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As a Post-Doctoral Fellow, you will conduct innovative research aimed at pioneering new understanding of macrophage-stromal cell interactions related to intestinal epithelial tissue injury and aberrant tissue remodeling mechanisms. A creative scientist is sought to uncover new pathways and mechanisms at the macrophage-stroma interface by leveraging recent technological advances in long-lived in vitro co-culture model systems which employ a combination of primary epithelial cells derived from human intestinal stem cells, mesenchymal stromal cells and primary human macrophages. In addition to actively working side-by-side with innovative drug discovery scientists of the Immunology & Respiratory Disease Research group in Ridgefield, CT, and collaborating with European colleagues also actively involved in this line of research, the post-doctoral scientist will be expected to initiation and publish research findings for scientific impact to the internal and external scientific community.

As an employee of Leading Pharmaceutical Company, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Leading Pharmaceutical Companys high regard for our employees.

Duties & Responsibilities:

The Post-Doctoral Fellow will propagate 3D human intestinal stem cell spheroid/organoid cultures and utilize these for development of new long-lived trans-well-based 2D culture systems that models well-differentiated human intestinal epithelium and underlying stroma.
Isolate and culture primary human intestinal mesenchymal stromal cells and primary human macrophages and employ these for innovative 2D/3D co-culture approaches and molecular profiling studies to illuminate mechanisms and new hypotheses relating to how diseased stroma influences macrophage differentiation, function and regulation of aberrant tissue and remodeling/fibrosis in the intestine.
Employ a combination of pharmacologic and genetic approaches to test prioritized hypotheses which will emerge from the molecular profiling studies.
Desired Experience, Skills and Abilities:

Very strong cell biology and molecular biology skills
Experience with primary intestinal epithelial spheroid/organoid culture systems
Experience with primary human stroma and/or macrophage co-culture models
Good knowledge of immune-mediated aberrant tissue remodeling and/or pro-fibrotic mechanisms and associated signaling pathways and mechanisms
Highly motivated to drive cutting edge research and deliver high-quality science

PhD Degree in cell biology, molecular, immunology, bioengineering, biochemistry or related discipline
Must be able to confidently excel in a highly collaborative research work environment and must have good oral and written communication skills

Associated topics: bacteria, dietary, dietetic, dietician, histologist, metabolism, nephrology, pharmaceutical, pharmacology, therapy

* The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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